Khalida F. Al-azawi
Mar 15, 2016
Citations
0
Influential Citations
3
Citations
Journal
Oriental journal of chemistry
Abstract
3-((4-(dimethylamino)benzylidene)amino)-2-methylquinazolin-4(3H)-one (3), 3-((4hydroxybenzylidene)amino)-2-methylquinazolin-4(3H)-one (4), 2-methyl-3-(pyrrolidin-2-ylideneamino) quinazolin-4(3H)-one (5) and 3,3'-((1,4-phenylenebis(methanylylidene)) bis(azanylylidene))bis(2methylquinazolin-4(3H)-one) (6) derived from 3-amino-2-methylquinazolin-4(3H)-one have been synthesized and characterized by elemental analysis, FT-IR, NMR techniques and screened to establish their potential as antioxidants against 1,1-diphenyl-2-picrylhydrazyl (DPPH) and Nitric oxide (NO) radical scavengers. The results revealed that synthesized compounds (5 and 6) are much higher than common antioxidants ascorbic acid and they showed excellent scavenging capacity against DPPH and Nitric oxide (NO). The synthesized compounds (3 and 4) demonstrated encouraging results comparable with ascorbic acid.