G. R. Nikhila, S. Batakurki, B. Yallur
Oct 5, 2020
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PROCEEDINGS OF INTERNATIONAL CONFERENCE ON ADVANCES IN MATERIALS RESEARCH (ICAMR - 2019)
Abstract
Heterocyclic compounds and their derivatives are prominent molecules in pharmaceutical industries for their various medicinal properties. Among various heterocyclic moieties benzo[4, 5]imidazo[2, 1-b]thiazole has gained lot of interest of synthetic organic chemist and biologist due to their potent pharmacological activities. The present work involves an efficient synthetic route for the synthesis of Bromomalonaldehyde from 1,1,3,3,-tetromethoxypropane and bromine under mild conditions. Further 2-mercaptobenzimidazole carbaldehyde synthesis from Bromomalonaldehyde and 2-marcaptobenzimidazole. Further condensation of 2-mercaptobenzimidazole carbaldehyde with primary amines yields novel Schiff base of benzo[4, 5]imidazo[2, 1-b]thiazole. All the synthesized compounds have been supported by infra-red spectroscopy, 1H nuclear magnetic spectrum and LC-M S spectral data for structural confirmation. The newly synthesized compounds have been screened for their antioxidant studies by DPPH method. Compound Benzo[4, 5]imidazo[2, 1-b]thiazole-2-carbaldehyde showed 95% inhibiton for 500 µg/lit when compared to 7-Nitrobenzo[4,5]imidazo[2,1-b]thiazole-2-carbaldehyde which showed 85% inhibton for 500 µg/ml. Among the sythesised Schiff bases, compound 1-(benzo[4,5]imida zole[2,1-b]thia zole-2-yl)-N -(4-nitrophenyl)methanimine showed 97.5% inhibition for 800 µg/ml.