Badugu Devendar, Chi-Phi Wu, Chi-Yuan Chen
Jun 17, 2013
Citations
0
Influential Citations
8
Citations
Journal
Tetrahedron
Abstract
Abstract Ethyl 4-ethoxyazulene-1-carboxylate ( 1 ) is highly efficient and novel substrate for electrophilic substitution reactions. These derivatives ( 2 – 4 ) were treated with NH 2 NH 2 /PhNHNH 2 in ethanol to produce pyridazine, and fulvene derivatives with azulene frameworks ( 5 , 6 , 17 , 19 ) via intramolecular cyclization. The substrates 5 – 8 , 11 , and 19 were effectively converted into densely functionalized heterocyclic molecules via Vilsmeier–Haack, Friedel–Crafts, and Michael addition reactions.