M. Rbaa, Omar Bazdi, A. Hichar
Feb 7, 2019
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Influential Citations
16
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Journal
Eurasian Journal of Analytical Chemistry
Abstract
We have synthesized a new pyran derivatives based on 8-hydroxyquinoline such as 2-Amino-4-phenyl-4H-pyrano [3,2-h] quinoline-3-carbonitrile (QP-H), 2-Amino-4-(4chlorophenyl)-4H-pyrano-[3,2-h] quinoline-3-carbonitrile (QP-Cl), 2-Amino-4-(4methoxyphenyl)-4H-pyrano-[3,2-h]quinoline-3-carbonitrile (QP-OCH3) and 2-Amino-4-(4nitrophenyl)-4H-pyrano[3,2-h]quinoline-3-carbonitrile (QP-NO2). All the synthesized compounds were identified by elemental analysis data, IR, 1H and 13C NMR spectroscopy and were evaluated and screened “in vitro” by the disk diffusion technique against Grampositive and Gram-negative bacterial strains (E. coli (ATCC35218), S. aureus (ATCC29213), V. parahaemolyticus (ATCC17802), and P. aeruginosa (ATCC27853)). The preliminary screening results showed that all the compounds displayed a potential antibacterial activity against all the tested four Gram bacteria. The results revealed that most of the tested compounds have a very good antibacterial activity compared to the standard antibiotic (Penicillin G).