Laijin Tian, Yu-xi Sun, Xiao‐Feng Zheng
Mar 1, 2007
Citations
2
Influential Citations
20
Citations
Journal
Chinese Journal of Chemistry
Abstract
The diorganotin(IV) complexes of N-(3,5-dibromosalicylidene)-α-amino acid, R′2Sn(2-O-3,5-Br2C6H2CHNCHRCOO)(where R=H, Me, i-Pr, Bz; R′ =n-Bu, Cy), were synthesized by the reactions of diorganotin dichlorides with in situ formed potassium salt of N-(3,5-dibromosalicylidene)-α-amino acid and characterized by elemental analysis, IR and NMR (1H, 13C and 119Sn) spectra. The crystal structures of n-Bu2Sn(2-O-3,5-Br2C6H2CHNCHRCOO)(R=i-Pr, Bz) and Cy2Sn(2-O-3,5-Br2C6H2CHNCHRCOO)(R=Me, Bz) were determined by X-ray single crystal diffraction and showed that the tin atoms are in a distorted trigonal bipyramidal geometry to form five- and six-membered chelate rings with the tridentate ligand. Bioassay results indicated that the compounds possess better in vitro antitumour activity against three human tumour cell lines, HeLa, CoLo205 and MCF-7, than cis-platin and moderate anti-bacterial activity against two bacteria, E. coli and S. aureus.