H. Kaur, S. Saxena, Ashok Kumar
2010
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Journal
International journal of pharma and bio sciences
Abstract
A series of 3-(5-(2-fluorophenyl)-1,3,4-thia diazol-2-yl)-2-((2-(5-(un/substituted hetetocyclic/ aryl) -4,5dihydroisoxazol-3-yl)hydrazinyl)methyl)quinazolin-4(3H)-ones 6a-i have been synthesized by the reaction of 3-(5-(2-fluorophenyl)-1,3,4-thiadiazol-2-yl)-2-((2- (5-(un/substituted heterocyclic/ arylchalconyl)hydrazinyl)methyl)-substitutedquinazolin-4(3H)-one 5a-5i with hydroxyl amine hydrochloride in presence of 2% NaOH. All the newly synthesized compounds were screened for their antipsychotic and anticonvulsant activities. Structures of all the compounds were established by elemental and spectral (IR, 1 H NMR and Mass) analysis.