C. Sanjeevarayappa, Pushpa Iyengar, E. ManojkumarK.
Dec 25, 2016
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international journal of engineering trends and technology
Abstract
Some new amides containing oxadiazole derivatives have been synthesized taking N-Boc piperazine as starting material. These were converted to N-cyano-4-Boc piperazine by nucleophilic substitution reaction. The substituted product was treated with hydroxyl amine hydrochloride in basic condition to give hydroxycarbamimide and cyclized with 3fluorobenzoic acid to yield N-protected piperazine 1,2,4-oxadiazole. Deprotection of secondary amine was done using trifluoro acetic acid, free secondary amine obtained was condensed with different substituted sulphonyl chlorides in the presence of triethyl amine to yield sulphanamides of piperazine containing 1,2,4-oxadiazole nucleus. The newly synthesized compounds were characterized by spectroscopic studies such as IR, 1 H NMR, 13 C NMR, LCMS and CHN elemental analysis. All the synthesized compounds were screened for their in vitro antibacterial activity, anthelmintic activity. Some of the compounds showed good biological activity.