Aziz‐ur‐Rehman, K. Nafeesa, M. Abbasi
Jun 30, 2013
Citations
0
Influential Citations
11
Citations
Journal
Pakistan Journal of Chemistry
Abstract
presented research work, a series of S-substituted derivatives of 5-(3-nitrophenyl)-1,3,4-Oxadiazole-2-thiol was synthesized from 3-nitrobenzoic acid. The synthesis was carried out by converting 3-nitrobenzoic acid correspondingly into ester, hydrazide and 5-(3-nitrophenyl)-1,3,4-Oxadiazole-2-thiol (4). Finally, the S-substituted derivatives (6a-m) were brought about by reacting 5- (3-nitrophenyl)-1,3,4-Oxadiazole-2-thiol with different electrophiles (5a-m) in the presence of NaH and N,N-dimethylformamide. Structure elucidation for all the synthesized compounds was executed by different spectroscopic analysis like IR, 1 H-NMR and EI-MS. All the synthesized derivatives were screened for antibacterial activity. Antibacterial potential was sorted out for four gram-negative bacteria including Shigella sonnei, Escherichia coli, Pseudomonas aeruginosa & Salmonella typhi; and two gram- positive bacteria including Bacillus subtilis & Staphylococcus aureus and found results that most of the compounds exhibit significant activity relative to the standard drugs Ciprofloxacin and Gentamycin.