M. Mubarak
Apr 1, 2017
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Journal
World journal of pharmaceutical research
Abstract
Piperidin is an important class of heterocyclic compounds which play a vital role in the field of medicinal chemistry. Several 2,6-disubstituted derivatives of these compounds are found to posses biological activities such as herbicidal, fungicidal, anticancer, anaesthetic etc. The synthesis of substituted piperidin-4-one derivatives using 2,4dinitrophenyl-hydrazine from1,3-diphenyl acetone, variously substituted aldehydes and ammonium formate (amine) in ethanol medium under reflux-free condition is described to get 2,3,5,6tetraphenyl-piperidinin-4-one. Which after incorporated with 2,4dinitrophenyl-hydrazine using reaction condition to get target compound N-(2,4-Dinitro-phenyl)-N’-(2,3,5,6-tetraphenyl-piperidin-4ylidine)-hydrazine. The characterized by FT-IR, 1 HNMR, 13 CNMR and Biological studies.