A. Saeed, Shahid Hussain, N. Abbas
Jun 1, 2009
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Influential Citations
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Journal
Chinese Journal of Chemistry
Abstract
Michael addition of some substituted anilines to methyl acrylate in acidic medium afforded the methyl 3-(substituted anilino)propionates ( 1a !1i ), which on treatment with hydrazine hydrate in methanol were converted into corresponding 3-(substituted anilino) propionohydrazides ( 2a !2i ) in good yields. Microwave irradiation of the latter with pentane-2,4-dione afforded 1-(3,5-dimethyl-1 H-pyrazol-1-yl)-3-(substituted anilino)propan-1-ones ( 3a ! 3i ) under solventless conditions. The structures were confirmed by spectroscopic data, elemental analyses and in case of the 3h by single crystal X-ray diffraction data.