Edward D. Cross, M. T. C. Ang, D. D. Richards
Sep 15, 2017
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Influential Citations
7
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Quality indicators
Journal
Inorganica Chimica Acta
Abstract
Abstract NS -containing ligands with the 2 - thioaniline motif and imine functional group linked phenyl, 2-pyridyl and 2-thienyl pendants were synthesized by imine condensation reactions with corresponding aldehydes. 2-(methylthio)- N -(2-thienylmethylene)-benzenamine is a new compound characterized by NMR, FTIR and UV–vis. Single crystal X-ray crystallographic data was obtained for all three ligands. The corresponding Cu(I) complexes were obtained by addition of CuBr in toluene/acetonitrile solutions affording the bis -bidentate NS - and SNS- complexes. Aerobic oxidation of one compound, the Cu(I) complex of 2-(methylthio)- N -(2-pyridylmethylene)-benzenamine, afforded the corresponding Cu(II) complex which was characterized by single crystal X-ray crystallography and presented a pentacoordinated CuBr 2 adduct of 2-(methylthio)- N -(2-pyridylmethylene)-benzenamine with a distorted square pyramidal coordination environment. Free ligands and the Cu complexes were screened for antimicrobial activity and 2-(methylthio)- N -(2-pyridylmethylene)-benzenamine copper(II) dibromide showed activity against B. cereus and S. aureus . The cytotoxicity of ligands and Cu complexes on mammalian cell cultures was assessed by the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide) assay on mouse macrophages cell line (J774.A1) and human breast cancer cell line (MCF7). The free NS -ligands showed good biocompatibility with both cell lines. Cu(I) and Cu(II) complexes showed significant effects on cell viability with dose-response dependency.