Xianmei Shang, Shaozhong Wei, Jianping Yan
Mar 22, 2013
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Quality indicators
Journal
Polyhedron
Abstract
Abstract Five new mononuclear butyl-hexyltin(IV) complexes with para-position substituents of N-hydroxybenzamide anions [para-position substituent = H (1), F (2), Cl (3), Br (4), I (5)], formulated as the [nBunHexSnL2] (Bu = butyl, Hex = hexyl, HL = substituted N-hydroxybenzamide), were prepared and characterized by elemental analyses, FT-IR, 1H, 13C, 119Sn NMR spectroscopies. Crystal structure of complex 2 was determined by X-ray diffraction analysis. The cytotoxicity was tested by SRB assay. The results indicate that the complex 5 with iodine atoms has the best cytotoxicity against KB cells, even being better than that of cisplatin. It suggests that both halogens and alkyl groups around tin have important effects on cytotoxicity.