D. M. Skytte, K. Frydenvang, Liselotte Hansen
Feb 18, 2010
Citations
0
Influential Citations
6
Citations
Journal
Journal of natural products
Abstract
8-Epitacrolimus (2), a new l-pipecolic acid macrolide lactone, was obtained by base-catalyzed epimerization of tacrolimus (FK-506, 1), an important immunosuppressive drug, and its structure determined by a single-crystal X-ray diffraction method. The compound was fully characterized by spectroscopic techniques. The epimer is of importance due to its potential biological effects as well as because of its possible formation during formulation, handling, and use of tacrolimus products.