K. Nafeesa, Aziz‐ur‐Rehman, M. Abbasi
Dec 1, 2017
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Influential Citations
5
Citations
Quality indicators
Journal
Bulletin of Faculty of Pharmacy, Cairo University
Abstract
Abstract A new series of N -substituted derivatives of 2-[(5-{1-[(4-chlorophenyl)sulfonyl]-3-piperidinyl}-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide ( 6a-w ) has been designed and synthesized with multifunctional moieties. The synthesized compounds were evaluated for their antibacterial and anti-enzymatic potential supported by % hemolytic activity. The synthesized compound 5-(1-(4-chlorophenylsulfonyl)-3-piperidinyl)-1,3,4-oxadiazole-2-thiol ( 3 ) was stirred with synthesized electrophiles as N -aryl/alkyl/aralkyl-2-bromoacetamide ( 5a-w ) in an aprotic solvent under basic conditions to acquire the target molecules, 6a-w . The spectral analytical techniques of IR, EI-MS, 1 H NMR and 13 C-NMR were utilized for structural elucidation of synthesized molecules. The antibacterial screening against certain bacterial strains of gram-negative and gram-positive bacteria rendered compound 6i as good inhibitor of gram-negative bacterial strains. The enzyme inhibition revealed low potential against lipoxygenase (LOX) enzyme. The hemolytic study provided valuable information about cytotoxic behavior of synthesized molecules.