A. Kale, K. M. Durgade
Dec 1, 2017
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Journal
International Journal of Scientific Research in Science and Technology
Abstract
Present work includes synthesis of 2-{[2-(piperazin-1-yl)quinazolin-4-yl]amino}ethan-1-ol (IV) , N2, N4-di ptolylquinazoline-2,4diamine (V) and N2, N4-bis(4-chlorophenyl)quinazoline-2,4-diamine (VI) which are quinazoline derivatives and out of these three quinazoline derivatives N2, N4-bis(4-chlorophenyl)quinazoline-2,4diamine (VI) have shown “antifungal activity” against fungus “Aspergillus flavus” and “antibacterial activity” against bacteria “Pseudomonas”. At first 2amino benzoic acid react with urea at temperature 130 oC to 140oC to gives Quinazolin-2,4-diol (I) which on further reaction with phosphorus oxychloride at 150 oC for 24 hr. to gives second product 2,4-dichloroquinazoline (II). Then 2-4-dichloroquinazoline (II) reacts with 2-aminoethan-1-ol and piperazine to gives 2-{[2-(piperazin-1-yl)quinazolin-4-yl]amino}ethan-1-ol (IV) and when p-toluidine react with 24-dichloroquinazoline (II) to gives N2, N4-di p-tolylquinazoline-2,4diamine (V) and again this 2,4dichloroquinazoline (II) react with p-chloroanline to gives N2, N4-bis(4-chlorophenyl) quinazoline-2,4-diamine (VI) which characterized by I. R., 1HNMR and 13CNMR.