A. Mohamod, M. Redayan, W. Ali
Sep 1, 2019
Citations
0
Influential Citations
3
Citations
Quality indicators
Journal
Journal of Physics: Conference Series
Abstract
Serious of some novel bis benzimidazole derivatives were designed and synthesized by nucleophilic substitution reaction of 5-(un)substituted-2-chloromethyl-1H-benzimidazole and 5-(un)substituted-2-mercapto-1H-benzimidazole in the presence of sodium in methanol. Spectral methods of analysis (FT-IR, 1H-NMR, and 13C-NMR) were used to confirm the structures of the synthesized compounds. Antibacterial activity were evaluated for most of the target compounds against four strains of bacteria including (E.coli, P. aeruginosa) as gram-negative bacteria and (B. subtilis, S. aureus) as gram-positive bacteria, the tested compounds showed various activity against both gram-negative and gram-positive bacteria used.