W. Pu
2004
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0
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Journal
Chinese Journal of Medicinal Chemistry
Abstract
Aim To improve the preparation process of topotecan hydrochloride.Method Topotecan hydrochloride was synthesized from camptothecin by improved hydrogenation oxidation and the Mannich reaction.Result and conclusion Topotecan hydrochloride was synthesized and characterized by elemental analysis,IR,UV, 1H NMR, 13 C NMR,ESI MS,etc.