Pan Hai-ya
2012
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Journal
Guangzhou Chemical Industry
Abstract
2-(4-carbosulfonylphenyl)-1-(6-methyl-3-pyridinyl)ethanone,a key intermediate of Etoricoxib,was synthesized from thioanisole via Friedel-Crafts acylation,Oxidation,Willgerodt-Kindler rearrangement,Claisen condensation with an overall yield of 39% and HPLC purity of 92.3% with further purification.4-(Methanesulfonyl)phenylacetic acid and 2-(4-Mesylphenyl)-1-(6-methylpyridin-3-yl)-ethan-1-one as key products were characterized with IR and NMR.