Xu Zhong-yu
2010
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Journal
Fine Chemical Intermediates
Abstract
(2S,4S)-2-Dimethylaminocarbonyl-4-mercapto-1-(4-nitrobenzyloxycarbonyl)pyrrolidine was synthesized from trans-4-hydroxy-L-proline in overall yield of 40.9% in few steps including N-acylation,sulfonylation,amidation,inversion of configuration and hydrolysis.The configuration inversion was assisted by microwave irradiation and thus the reaction time was shortened and nitrogen protection dismissed.The target compound and intermediates were identified with 1H NMR,IR,MS and OR.