Nadimenti Mogulaiah, P. Sundar, Tasleem
Mar 29, 2018
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Journal
International research journal of pharmacy
Abstract
A series of novel (R)-2-{[5-bromo-1-(3-bromopropyl)-1H (substituted)-indol-3-yl]methyl}pyrrolidine-1-carboxylic acid (T1-T5) derivates were synthesized by electrophilic substitution at 1st position of (R)-2-{[5-bromo-1-(3-bromopropyl)-1H-indol-3-yl]methyl}pyrrolidine-1-carboxylic acid with various halides. The starting material (R)-2-{[5-bromo-1-(3-bromopropyl)-1H-indol-3-yl]methyl}pyrrolidine-1-carboxylic acid was synthesized from 4-bromo aniline by japp-klingemann and fischer indole cyclization reactions. The synthesized compounds were characterized by IR, 1H NMR MASS spectroscopy.