Cheng De-ju
2014
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Journal
Journal of Inner Mongolia Normal University
Abstract
4-bromo-2-(bromomethyl)-1-((4-chlorobenzyl)oxy)benzene(Ⅲ)was synthesized from1-chloro-4-(chloromethyl)benzene and 5-bromo-2-hydroxybenzaldehyde by elimination reaction,reduction reaction and bromization.N-allyl-3-chloro-N-(piperidin-4-yl)benzamide(Ⅳ)was prepared from piperidin-4-one.Then a novel non-peptide CCR5 antagonist of N-allyl-N-(1-(5-bromo-2-((4-chlorobenzyl)oxy)benzyl)piperidin-4-yl)-3-chlorobenzamide was obtained from Ⅲ and Ⅳ,The structures of the products were characterized by 1 HNMR,13 CNMR and MS.