Nami Navabeh, Kazemi Seyed Marziyeh
Dec 1, 2015
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Journal
Quarterly Journal of Applied Chemical Research
Abstract
Reaction of thionyl chloride with 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4oxoquinoline-3-carboxylic acid 1 gave acid chloride 2. Compound 2 was reacted with glycine and D-glutamic acid to afford 2-(7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4dihydroquinoline-3-carbonyl) aminopantandioicacid 3a and 2-(7-chloro-1-cyclopropyl-6fluoro -4oxo-1,4-dihydroquinoline-3-carbonyl)aminoaceticacid 3b. These compounds were changed to chloromethyl ketone derivatives 5a-b from diazomethane and then HCl (g) in dry diethyl ether.