H. Faidallah, K. A. Khan, A. Asiri
Jun 30, 2011
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0
Influential Citations
20
Citations
Journal
European Journal of Chemistry
Abstract
Arylhydrazines reacted with dehydroacetic acid ( 1 ) to give the corresponding 2 H -pyran-2-one hydrazones ( 2 ), which on treatment with hydrazine hydrate afforded the corresponding 1-amino-2 H -pyridin-2-ones ( 3 ). Reaction of 3 with nitrous acid, aromatic aldehyde and substituted benzenesulfonyl chlorides yielded the corresponding 2 H -pyridine-2-one derivatives. A series of urea and thiourea derivatives were also prepared. Some of these compounds have shown significant antibacterial and mild to moderate antimycobacterial and antifungal activities.