Y. Trukhanova, D. A. Kolesnik, I. Yakovlev
Oct 1, 2021
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Abstract
Abstract The reaction of N-arylbenzenecarboximidamides 1a-e with succinic anhydride 2 was studied, leading to the formation of (Z)-1-phenyl(arylamino)methylpyrrolidine-2,5-diones 3a-e in good yields. The structure of the obtained compounds was proved by 1H, 13C NMR, IR, MS (ESI) and elemental analyzes. For (Z)-1-phenyl(phenylamino)methyl)pyrrolidine-2,5-dione 3a, an X-ray diffraction analysis was performed and an in vivo study of analgesic activity in laboratory mice was carried out.