D. Savage, G. Malone, J. Gallagher
Jan 17, 2005
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0
Influential Citations
30
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Journal
Journal of Organometallic Chemistry
Abstract
Abstract A series of N - para -ferrocenyl benzoyl amino acid ethyl esters 1–8 have been prepared by coupling para -ferrocenyl benzoic acid with the amino acid esters using the conventional 1,3-dicyclohexylcarbodiimide (DCC), 1-hydroxybenzotriazole (HOBt) protocol. The amino acids employed in the synthesis were glycine, l -alanine, l -leucine, l -phenylalanine, β-alanine, 4-aminobutyric acid, (±)-2-aminobutyric acid and 2-aminoisobutyric acid. The compounds were fully characterized by a range of spectroscopic techniques such as NMR and mass spectrometry. In addition the X-ray crystal structures of the glycyl 1 and (±)-2-aminobutyrate 7 derivatives have been determined. Analysis of relevant fragments in crystal structures on the Cambridge Structural Database indicates a relative paucity of common fragments such as the α-aminobutyrate group in comparison to the glycyl moiety.