Chen Qi-fan
2010
Citations
0
Influential Citations
0
Citations
Journal
Journal of Eastern Liaoning University
Abstract
With succinic anhydride as the raw material,five N-substituted succinamic acid compounds were synthesized by its acylating reaction with 2-amino pyridine,N-methyl piperazine,p-chloroaniline,aniline,tertiary butyl amine,respectively.The optimum reaction conditions are as follows: the ratio of succinic anhydride to amine is 1:1;the reaction temperature is 15 ℃ and reaction time 5 hours;the dosage of dichloromethane as reaction medium is 160 mL.The highest yield of five object compounds is 85.6%,82.4%,78.4%,74.3% and 71.9%,respectively.The synthetic products are purified through re-crystallization and their structures are characterized by the 1HNMR.