H. Ide, M. Okagami, H. Murayama
Nov 1, 1993
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0
Influential Citations
11
Citations
Journal
Biochemistry and molecular biology international
Abstract
The alpha-anomer of 2'-deoxyadenosine 1 is a major adenine lesion produced by hydroxyl radicals in DNA. To assess its biochemical effects on DNA replication, 1 was site-specifically incorporated into oligonucleotide templates using phosphoramidite chemistry. The templates were purified and extensively characterized to ensure their homogeneity and nucleotide sequences.