Zhou Peng
2004
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Journal
Journal of Hunan University
Abstract
2-(6-methoxy-2-naphthyl)-3-methyl-4-(2-hydroxyethyl)-2-morpholinol,2-(3-chlorophenyl)-3-methyl-4-(2-hydroxyethyl)-2-mospholinol, 2-(4-benzyloxyphenyl)-3-methyl-4-(2-hydroxyethyl)-2-morpholinol and 2-(4-benzyloxyphenyl)-3-propyl-4-(2-hydroxyethyl)-2-morpholinol were synthesized through the reactions of 6-methoxy-2-(2-bromopropionyl)naphthalene, α-bromo-3-chloropropiophenone, α-bromo-4-benzyloxypropiophenone and α-bromo-4-benzyloxypento-phenone with diethanolamine at 50 ℃ with 1 h stiring. The 2-aryl-4-(2-hydroxyethyl)-2-morpholinols reacted with hydrochloride to obtain the hydrochloride salt with a yield of (58.3%)~89.8%. The structures of the hydrochloride salts of 2-aryl-4-(2-hydroxyethyl)-2-morpholinols were characterized with ()~1H NMR,()~1H-()~1H COSY, IR and MS spectra.