R. Srikanth, A. Sivarajan, B. Sivakumar
2014
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Journal
International journal of pharma and bio sciences
Abstract
Acetic acid promoted one-pot Mannich type condensation involving long chain ketones results in the formation of 3-substituted or 3,5-disubstituted 2,6-diarylpiperidin-4-ones in moderate yields. In the absence of acetic acid, the reaction does not proceed to completion. The six member heterocyclic ring adopts a chair conformation, with equatorial disposition of all the substituents. Among the different derivatives of piperidine-4-one, derivatives containing tetrazole and semicarbazone are more potent than the alkyl derivatives against bacteria and fungi.