Wasfi A. Al-Masoudi, H. Mohammad, Adel Hama
2015
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Abstract
Condensation of 4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylic acid,6-[[amino(4-hydroxy phenyl) acetyl]amino]-3,3-dimethyl-7-oxo,trihydrate with 2hydroxy-1naphthaldehyde yielded a novel Schiff base derivative of amoxicillin in good yield. A new compound was characterized by elemental analysis, IR, and H-NMR spectroscopy. The synthesized compound was screened for antibacterial activity against Staphylococcus aureus, Escherichia coli, Bacillus cereus, Streptococcus, Klebsella, salmonella and Psedumonas spp and fungicidal activity against Aspergillus multi, Aspergillus niger, Candida albicans, Candida trobicalis and Candida krusi. The toxicity of the compound was also assayed via the determination of their LD50 value by using Dixons up and down method (1980). Studied compound was found to have an LD50 of 492.8 mg / kg of body weight.