Tulika Sharma, Vinit, Sakshi
Aug 1, 2020
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Chemical Data Collections
Abstract
Abstract 1-(2-Arenethyl)-3, 5-dimethyl-1H-pyrazoles (4a-g) were obtained by Wolff-Kishner reduction of 2-(3,5-Dimethyl-1H-pyrazol-1-yl)-1-arylethanones (3a-g). The synthesized compounds were characterized by analyzing their IR, 1H, and 13C-NMR spectral data. Intermediates (3a-g) were synthesized by the solid phase reaction of 3, 5-dimethylpyrazole with different substituted phenacyl bromides under basic condition by adopting reported procedure. All synthesized compounds were screened in vitro for their anti-bacterial potential against four bacterial strains and it was found that the compounds 4c and 4g bearing methoxy and nitro group, respectively, exhibited good level of inhibitory potential which was about 25% of the standard drug, Ciprofloxacin- against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa bacterial strains. Further, DNA photocleavage ability was also explored and it was observed that compounds bearing halogen group (4d, 4e and 4f) displayed good DNA photocleavage activity.