Shams A. Nadhum, M. H. Mohammed
Dec 1, 2020
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Journal
Annals of Tropical Medicine and Public Health
Abstract
2-((9H-purin-6-ylthio) carbonothioyloxy) ethyl 1, 3-dioxoisoindolin-2 yl carbamodithioate (IV) and 2 – oxo -2 (thiazol-2-ylamino) ethyl 1, 3 dioxoisoindolin-2-ylcarbamodithioate (VI), are synthesized from conjugation of 6-mercataptopurine or 2-aminothiazole with N-aminophthalimide using dithiocarbamate as spacer. The generation of the compounds (IV) and (VI) was accomplished following multistep reaction procedures. The reaction and purity of the products were checked by melting points, and the structures of the synthesized were supported using Infrared (IR), 1H NMR, 13 C NMR spectroscopy and Elemental micro analyses.