Zhang Sheng-yong
2007
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Chemical Reagents
Abstract
(S)-(+)-2-(2-Naphthyl)-2-(N-methyl) aminoethanol was synthesized from(R)-1-naphthalen-2-ylethane-1,2-diol produced by the Sharpless asymmetric dihydroxylation,cyclization of diols,azide opening of epoxides,catalytic hydrogenation of the resulting azido alcohols,formylation of the chiral β-amino alcohol and reduction of the corresponding formamide.The six-step procedure starting from 2-vinylnaphthalene resulted in a total yield of 39.7% with the e.e.values reaching up to 97%~99%.Its structure was characterized by IR,1HNMR,13CNMR and MS.