N. Zanatta, S. S. Amaral, Andressa Esteves-Souza
Jun 28, 2006
Citations
1
Influential Citations
36
Citations
Journal
Synthesis
Abstract
The synthesis of some potentially active 2-(trifluoro-methyl)pyrimido[1,2-a]benzimidazoles and pyrimido[1,2-a]benzimidazol-2(1H)-ones by the cyclization of 4-alkoxyvinyl trifluoro(chloro)methyl ketones with 2-aminobenzimidazole is described. The structure of the products was assigned based on 'H and 13 C NMR as well as 2D-NMR experiments. Some of the obtained products exhibited significant DNA-topoisomerase I inhibitory activity.