Emel Guney, V. Yilmaz, F. Arı
Jan 12, 2011
Citations
0
Influential Citations
69
Citations
Quality indicators
Journal
Polyhedron
Abstract
Abstract New palladium(II) and platinum(II) complexes containing bis(2-pyridylmethyl)amine (bpma) and saccharinate (sac), [Pd(bpma)(sac)](sac)·2H 2 O ( 1 ), [Pt(bpma)(sac)](sac)·2H 2 O ( 2 ), [Pd(bpma)Cl](sac)·2H 2 O ( 3 ) and [Pt(bpma)(sac)]Cl·1.5H 2 O ( 4 ), were synthesized and characterized by elemental analysis, IR, NMR and TG-DTA. A single-crystal X-ray analysis of 3 and 4 proved a distorted square–planar geometry around the metal ions with one tridentate bpma ligand and one Cl or sac monoanion. The [Pd(bpma)Cl] + ions in 3 form dimers by intermolecular N–H⋯Cl and Pd⋯Pd interactions. The cations reside in the centers of a hydrogen-bonded honeycomb network formed by the uncoordinated sac ions and the lattice water molecules, while the cations of 4 are connected by N–H⋯Cl and OW–H⋯O hydrogen bonds into one-dimensional chains. Cyclic planar tetrameric and trimeric water clusters were observed in 3 and 4 , respectively. Cytotoxicity of 1 – 4 was tested against A549, C6 and CHO cells. Although 2 and 4 have no cytotoxicity, the best results were achieved for 1 and 3 . In particular, the cyctotoxic activity of 3 is comparable to cisplatin.