R. Udhayasurian, K. Sivakumar, A. Sankar
2020
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Journal
Annals of Tropical Medicine and Public Health
Abstract
A series of molecules containing sulfonyl and amide coupling structure were developed, synthesized and characterized. Sulfonamides are a very important class of compounds in the pharmaceutical industry. In this work, a new class of sulfonamide derivatives is being synthesized from 4-aminobenzene-1-sulfonamide with benzoic acid and its derivatives (1a-ah) using peptide coupling reagent EDCI and HOBt with different melting point. The progress of reaction was monitored by the use of thin layer chromatography and the structures of the synthesized compounds were elucidated and confirmed by FT-IR, 1 H NMR and 13 C -NMR spectroscopic analysis.