Liu Tian-yu
2010
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Journal
Fine chemicals
Abstract
2-Mercapto-5-methoxyimidazo[4,5-b]pyridine was prepared with 2,6-dichloropyridine as the raw material,by the methoxylation with methanol/sodium hydroxide,then nitration with potassium nitrated/concentrated sulfuric acid,and ammonolysis with ammonia solution to obtain 2-amino-6-methoxy-3-nitropyridine(Ⅲ)which was finally reduced by tin chloride under 75 ℃ for 4 h and cyclized by carbon disulfide to give the target compound.The overall yield reached 43.6%.The structure of the product was characterized by IR,1HNMR and MS spectra.