H. A. Ali, Asia M. Shalash, M. Akkawi
Nov 1, 2017
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0
Influential Citations
12
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Journal
Applied Organometallic Chemistry
Abstract
Metal carboxylate compounds with nitrogen- and/or oxygen-donor ligands with various carboxylate coordination modes, monodentate, bidentate and bridging bidentate, have been shown to be important from biological and chemical aspects. Five zinc ion binary compounds, diaqua-bis-(2-((E)-5-fluoro-2-methyl-1-(4-(methylsulfinyl)benzylidene)-1H–inden-3-yl)acetato)zinc(II) (1), aqua-bis-(2-((E)-5-fluoro-2-methyl-1-(4-(methylsulfinyl)benzylidene)-1H–inden-3-yl)acetato)pyridin-2-aminezinc(II) (2), (2-((E)-5-fluoro-2-methyl-1-(4-(methylsulfinyl)benzylidene)-1H–inden-3-yl)acetato) pyridin-2-ylmethanaminezinc(II) (2-((E)-5-fluoro-2-methyl-1-(4-(methylsulfinyl)benzylidene)-1H–inden-3-yl)acetate) (3), bis-(2-((E)-5-fluoro-2-methyl-1-(4-(methylsulfinyl)benzylidene)-1H–inden-3-yl)acetato)-1,10-phenanthrolinezinc(II) (4) and bis-(2-((E)-5-fluoro-2-methyl-1-(4-(methylsulfinyl)benzylidene)-1H–inden-3-yl)acetato)-1,10-phenanthrolinezinc(II) (5), have been prepared and fully characterized. In addition, the complexes were evaluated for their antibacterial activity using the in vitro agar diffusion method against two Gram-positive (Staphylococcus epidermidis, Staphylococcus aureus) and two Gram-negative (Bordetella, Escherichia coli) bacteria and yeast species (Saccharomyces and Candida). Complex 5 showed reasonable activity against yeast. All compounds showed greater antibacterial activity against Gram-positive than Gram-negative bacteria. Results indicated that the efficiency of complex 5 in preventing the formation of β-hematin was 67.6%. The efficiency of chloroquine as a standard drug was reported as 93%. Furthermore, the phosphatase activity of the Zn(II) complexes was studied and results indicated an effect of the zinc complexes on phosphatase activity.