S. Shukla, A. Bishnoi, P. Devi
Jun 1, 2019
Citations
0
Influential Citations
2
Citations
Journal
Russian Journal of Organic Chemistry
Abstract
A series of 5,5′-(arylmethylene)bis[1,3-dimethyl-6-(methylamino)pyrimidine-2,4(1H,3H)-diones] have been synthesized by 2: 1 condensation of 1,3-dimethylbarbituric acid with armatic aldehydes in the presence of methylamine. The synthesized compounds have been characterized by 1H and 13C NMR, IR, and mass spectra and tested for their in vitro antibacterial activity against Bacillus subtilis, Staphylococcus aureus, and Pseudomonas aeruginosa. Some of the compounds have shown antibacterial activity exceeding that of ampicillin used as reference drug.