Ma Yu-zhuo
2010
Citations
0
Influential Citations
0
Citations
Journal
Fine Chemical Intermediates
Abstract
(S)-1-(2-Chloroacetyl)pyrrolidine-2-carbonitrile was synthesized from L-proline via the processes of N-chloroacetion,cabboxyl amination and carboxamide dehydration.The structures of the intermediates and the target compound were confirmed by 1H NMR and MS.Effect of the process conditions on reaction was investigated and the optimum parameters were obtained.The target compound was achieved in an oveval yield of 42.3%.The synthetic route has advantage of lower cost,simple operation and mild reaction condition.