Adem Çinarli, Demet Gürbüz, A. Tavman
Aug 4, 2011
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Journal
Bulletin of The Chemical Society of Ethiopia
Abstract
A series of 4-chloro-2-[(arylmethylidene)amino]phenols ( 1 – 11 ) including methoxy group were synthesized using appropriate synthetic route. The structures of the Schiff bases were characterized by FT-IR, UV-Vis, ESI-MS, 1 H and 13 C-NMR spectroscopic techniques and analytical methods. A relation is observed between melting points and existence of intramolecular hydrogen bonding. IR spectra of the compounds including and not including hydrogen bonding were compared. The compounds 2 and 4 show the characteristic UV bands attributed to the NH-forms. According to the 1 H-NMR spectral data the compound 2 has the strongest intramolecular hydrogen bonding and the compound 6 shows two isomeric structure. On the other hand, antibacterial and antifungal activities of the compounds were investigated. Most of the compounds show selective activity toward S. epidermidis and C. albicans . KEY WORDS : Schiff base, 4-Chloro-2-aminophenol, Antimicrobial activity Bull. Chem. Soc. Ethiop. 2011 , 25(3), 407-417.