Justin O. Massing, R. Planalp
Jul 22, 2015
Citations
0
Influential Citations
2
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Herein we report an efficient eight-step synthesis of N1-(3-(methylthio)propyl)-2-((3-(methylthio)propyl)thio)benzene-1,4-diamine (1) from 6-nitrobenzo[d]thiazole. Incorporation of a nitro rather than a hydroxyl functionality off the aromatic ring serves to enhance conversion during thia- and aza-conjugate additions. Ultimate reduction of the nitro substituent affords a bifunctional Cu(I) chelate in gram-scale quantities for subsequent sensing applications.