I. Gerus, Nataliya A. Tolmachova, S. Vdovenko
May 1, 2005
Citations
0
Influential Citations
27
Citations
Journal
Synthesis
Abstract
A number of 3-acylamino-6-polyfluoroalkyl-2H-pyran2-ones 3 were synthesized from β-alkoxyvinyl polyfluoroalkyl ketones 1 and N-acylglycines 2 in acetic anhydride in high yield. The reactions of trifluoromethyl-containing 2H-pyran-2-one 3b with 0-and N-nucleophiles were studied and 3-N-benzoylamino-6-hydroxy-6-trifluoromethyl-5,6-dihydro-2H-pyran-2-one (13), 3-N-benzoylamino-6-hydroxy-6-trifluoromethyl-5,6-dihydro-2H-pyridin-2-one (14a), and N- and 0-substituted 3-(N-benzoylamino)-6-trifluoromethyl-2H-pyridin-2-ones (15c,e, and 16) were synthesized.