D. Kravchenko, V. Kysil, Alexey P. Ilyn
Mar 1, 2006
Citations
0
Influential Citations
6
Citations
Journal
Synthetic Communications
Abstract
Abstract The article describes an effective synthesis and chemical transformations of 6‐(morpholine‐4‐sulfonyl)‐2,3,4‐quinolinetricarboxylic acid. The key step is the Pfitzinger reaction of 3,3‐dichloro‐2‐oxo‐2,3‐dihydro‐1H‐indole with diethyl 2‐oxosuccinate. Selective 2‐decarboxylation of the tricarboxylic acid followed by reaction of the resulting anhydride with a primary amine led to the formation of the 1,3‐dioxo‐2,3‐dihydro‐1H‐pyrrolo[3,4‐c]quinoline scaffold with interesting pharmacological activity.