Song Cheng-gang
2009
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Journal
Shandong Chemical Industry
Abstract
(3R,4R)-4-acetoxy-3-[(1'R-tert-butyl-dimethylsilyloxy)-ethyl]-2-azetidinone (4AA) was prepared from (3S,4S)-4-carboxyl-3-[(1'R-tert-butyl-dimethylsilyloxy)-ethyl]-1-p-methoxyphenyl-2-azetidinone through two-step process,involving the decarboxylation oxidation reaction which was catalyzed by manganese porphyrin and oxidized,and the reaction of oxidation using O3. The total yield of the reaction reached 83.7%. The use of manganese porphyrin catalyst raised the yield of this step to 93.0%.The product was characterized by means of FT-IR and 1HNMR.