Ding Cheng-ron
2015
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Journal
Fine chemicals
Abstract
3-Iodo-N1-(2-methyl-4-perfluoropropane-2-yl)-N2-[2-methyl-1-(methylsulfinyl) propan-2-yl phenyl]phthalamide was synthesized from isobenzofuran-1,3-dione via amidation,oxidization,and iodination.The effects of the mole ratio of materials,the amount of catalyst,reaction temperature and time on the yield of product were studied.In the improved process,after 4 steps,the total yield could reach 61.1%,and the purity of product was 96.5%.The structures of all the intermediates and the target product were characterized by means of1 HNMR and ESI-MS.The recovery and reuse of Palladium carbon could reduce the economic costs.This synthetic route is characterized by costeffectiveness,simple operation and high yield,holding out a promising future for industrialized application.