An Chenhon
2015
Citations
0
Influential Citations
1
Citations
Journal
Chinese Journal of Pharmaceuticals
Abstract
2-Methyl-3-amino-4-acethylanisole(2) was prepared from 2-methyl-3-nitrophenol via methylation,Friedel-Crafts reaction and reduction.2-(4-Isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-ol,the key intermediate of anti-HCV drug simeprevir,was synthesized from 3-methyl-2-butanone by bromination,cyclization,Sandmeyer reaction,cyano-substitution,and hydrolysis to give 4-isopropylthiazole-2-formic acid(3),which was subjected to chlorination,N-acylation with 2,and cyclization in the presence of t-BuOK.The overall yield was about 9%(based on3-methyl-2-butanone).