Chen Si-haia
2011
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Journal
Journal of Jiaxing University
Abstract
We researched on the asymmetric synthesis of 2,6-dimethyl-4-(3-nitrate yl) phenyl-1,4-dihydro-pyridine-3-ethyl-5-carboxylate by methyl acetoacetate and ethyl acetoacetate and ammonia and 3-nitrobenzaldehyde as the raw material at chiral phase transfer catalyst benzyl bromide in the solvent of anhydrous ethyl alcohol.As a result,the ee value is 45%,melting point is 163~164℃,yield is 85.7%.The structure of the product was characterized via X-diffraction,infrared spectroscopy,polarimetry and nuclear magnetic resonance spectroscopy.Polarimeter measurement revealed that the isomer is levo isomer;and the product is R-type proved by the analysis of X-diffraction crystal structure.