Cao Xiao-qun
2005
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Journal
Journal of Taishan Medical College
Abstract
Objective: To study the simple synthetic methods of chloromethyl pivalate.Methods: Pivaloyl chloride was prepared by the reaction of pivalic acid with thionyl chloride in the presence of e-Caprolactam in a chlorinated hydrocarbon medium(methylene chloride) at 20 ℃~35 ℃ with paraformaldehyde in the presence of Zinc chloride and thionyl chloride in methylene chloride at 20 ℃~35 ℃.Results: The yield of chloromethyl pivalate was 94.2%.Its structure was confirmed by IR and 1H NMR.Conclusion: The one-step method is simple and valuable for further development in industry.