Sampath Kumar Bandari, B. Kammari, Jyothi Madda
Mar 1, 2017
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Influential Citations
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Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
New chromeno carbamodithioates (7a-i), have been synthesized from 2, 3-dimethyl-7-(oxiran-2-ylmethoxy)-4H-chromen-4-one (5), carbondisulphide and commercially available acyclic and cyclic secondary amines in acetonitrile with good to excellent yields. The free radical scavenging activity of novel chromone-carbamodithioate analogues was quantitatively estimated by spectrophotometric method. Whereas, molecular docking studies were performed with the active site of cyclooxygenase-2 to identify hydrogen bonding, hydrophobic and ionic interactions between protein and ligands. The compounds 7g and 7h demonstrated potent antioxidant activity with IC50 of 1.405±0.019mM and 1.382±0.35mM respectively compared to Ascorbic acid.